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1

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth

Journal:

Year:

2013

Language:

english

File:

PDF, 1.93 MB

english, 2013

2

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins

Hockings, Colin, Alsop, Amber E., Fennell, Stephanie C., Lee, Erinna F., Fairlie, W. Douglas, Dewson, Grant, Kluck, Ruth M.

Journal:

Cell Death & Differentiation

Year:

2018

Language:

english

File:

PDF, 3.91 MB

english, 2018

3

HIV recency testing: should results be disclosed to individuals tested?

Abdool Karim, Quarraisha, Macklin, Ruth, Gruskin, Sofia, Klucking, Sara, Lockett, Lejeune, Maxwell, Celia J, Mayer, Kenneth H, Sanders, Edwin, Sawe, Frederick

Journal:

Journal of the International AIDS Society

Year:

2020

File:

PDF, 92 KB

2020

4

The mitochondrial gateway to cell death

Danielle J. Smith, Heling Ng, Ruth M. Kluck, Phillip Nagley

Journal:

Year:

2008

Language:

english

File:

PDF, 311 KB

english, 2008

5

A Single Cell Analysis of Apoptosis: Ordering the Apoptotic Phenotype

JOSHUA C. GOLDSTEIN, RUTH M. KLUCK, DOUGLAS R. GREEN

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 1.38 MB

english, 2000

6

Molecular biology of Bax and Bak activation and action

Dana Westphal, Grant Dewson, Peter E. Czabotar, Ruth M. Kluck

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2011

Language:

english

File:

PDF, 1012 KB

english, 2011

7

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

Grant Dewson, Tobias Kratina, Huiyan W. Sim, Hamsa Puthalakath, Jerry M. Adams, Peter M. Colman, Ruth M. Kluck

Journal:

Year:

2008

Language:

english

File:

PDF, 2.01 MB

english, 2008

8

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

Grant Dewson, Tobias Kratina, Peter Czabotar, Catherine L. Day, Jerry M. Adams, Ruth M. Kluck

Journal:

Year:

2009

Language:

english

File:

PDF, 968 KB

english, 2009

9

Spontaneous apoptosis in NS-1 myeloma cultures: Effects of cell density, conditioned medium and acid pH

Kluck, Ruth M., Chapman, Debra E., Egan, Michael, McDougall, Catherine A., Harmon, Brian V., Moss, Dennis J., Kerr, John F.R., Halliday, June W.

Journal:

Year:

1993

Language:

english

File:

PDF, 2.39 MB

english, 1993

10

Ordering the Cytochrome c-Initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9-Dependent Manner

Elizabeth A. Slee, Mary T. Harte, Ruth M. Kluck, Beni B. Wolf, Carlos A. Casiano, Donald D. Newmeyer, Hong-Gang Wang, John C. Reed, Donald W. Nicholson, Emad S. Alnemri, Douglas R. Green and Seamus J.

Journal:

The Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 4.07 MB

english, 1999

11

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

Ruth M. Kluck, Mauro Degli Esposti, Guy Perkins, Christian Renken, Tomomi Kuwana, Ella Bossy-Wetzel, Martin Goldberg, Terry Allen, Michael J. Barber, Douglas R. Green and Donald D. Newmeyer

Journal:

The Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 3.48 MB

english, 1999

12

Mitochondrial Permeabilization Relies on BH3 Ligands Engaging Multiple Prosurvival Bcl-2 Relatives, Not Bak

Rachel T. Uren, Grant Dewson, Lin Chen, Stephanie C. Coyne, David C. S. Huang, Jerry M. Adams and Ruth M. Kluck

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 2.78 MB

english, 2007

13

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

Brouwer, Jason M., Westphal, Dana, Dewson, Grant, Robin, Adeline Y., Uren, Rachel T., Bartolo, Ray, Thompson, Geoff V., Colman, Peter M., Kluck, Ruth M., Czabotar, Peter E.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.40 MB

english, 2014

14

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Westphal, Dana, Dewson, Grant, Menard, Marie, Frederick, Paul, Iyer, Sweta, Bartolo, Ray, Gibson, Leonie, Czabotar, Peter E., Smith, Brian J., Adams, Jerry M., Kluck, Ruth M.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

15

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

Fleming, Peter, Kvansakul, Marc, Voigt, Valentina, Kile, Benjamin T., Kluck, Ruth M., Huang, David C. S., Degli-Esposti, Mariapia A., Andoniou, Christopher E., Barry, Michele

Journal:

Year:

2013

Language:

english

File:

PDF, 1.37 MB

english, 2013

16

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis

Alsop, Amber E., Fennell, Stephanie C., Bartolo, Ray C., Tan, Iris K. L., Dewson, Grant, Kluck, Ruth M.

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 1.77 MB

english, 2015

17

A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect

ABDULLAEV, Ziedulla Kh., BODROVA, Marina E., CHERNYAK, Boris V., DOLGIKH, Dmitry A., KLUCK, Ruth M., PEREVERZEV, Mikhail O., ARSENIEV, Alexander S., EFREMOV, Roman G., KIRPICHNIKOV, Mikhail P., MOKHOV

Journal:

Biochemical Journal

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

18

Physiological restraint of Bak by Bcl-x L is essential for cell survival

Lee, Erinna F., Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M., Gray, Daniel H., Witkowski, Matthew T., Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Phi

Journal:

Genes & Development

Year:

2016

Language:

english

File:

PDF, 498 KB

english, 2016

19

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

Oliver von Ahsen, Christian Renken, Guy Perkins, Ruth M. Kluck, Ella Bossy-Wetzel and Donald D. Newmeyer

Journal:

The Journal of Cell Biology

Year:

2000

Language:

english

File:

PDF, 3.48 MB

english, 2000

20

“Radiochemically Pure [1-14C]Valproic Acid”—A Mixture of Labeled Structural Isomers

Dickinson, Ronald G., Wood, Brian T., Kluck, Ruth M., Hooper, Wayne D.

Journal:

Therapeutic Drug Monitoring

Year:

1986

File:

PDF, 255 KB

1986

21

A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect

ABDULLAEV, Ziedulla Kh., BODROVA, Marina E., CHERNYAK, Boris V., DOLGIKH, Dmitry A., KLUCK, Ruth M., PEREVERZEV, Mikhail O., ARSENIEV, Alexander S., EFREMOV, Roman G., KIRPICHNIKOV, Mikhail P., MOKHOV

Journal:

Biochemical Journal

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

22

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Brasacchio, Daniella, Alsop, Amber E, Noori, Tahereh, Lufti, Mariam, Iyer, Sweta, Simpson, Kaylene J, Bird, Phillip I, Kluck, Ruth M, Johnstone, Ricky W, Trapani, Joseph A

Journal:

Cell Death & Differentiation

Year:

2017

Language:

english

File:

PDF, 1.52 MB

english, 2017

23

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

Iyer, Sweta, Anwari, Khatira, Alsop, Amber E., Yuen, Wai Shan, Huang, David C. S., Carroll, John, Smith, Nicholas A., Smith, Brian J., Dewson, Grant, Kluck, Ruth M.

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 2.54 MB

english, 2016

24

Pore formation by dimeric Bak and Bax: an unusual pore?

Uren, Rachel T., Iyer, Sweta, Kluck, Ruth M.

Journal:

Philosophical Transactions Biological Sciences

Year:

2017

Language:

english

File:

PDF, 1.11 MB

english, 2017

25

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

Li, Mark Xiang, Tan, Iris K. L., Ma, Stephen B., Hockings, Colin, Kratina, Tobias, Dengler, Michael A., Alsop, Amber E., Kluck, Ruth M., Dewson, Grant

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.31 MB

english, 2017

26

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

Yeo, Janet H. C., Skinner, Jarrod P. J., Bird, Matthew J., Formosa, Luke E., Zhang, Jian-Guo, Kluck, Ruth M., Belz, Gabrielle T., Chong, Mark M. W., Lightowlers, Robert

Journal:

Year:

2015

Language:

english

File:

PDF, 2.82 MB

english, 2015

27

Ensemble Properties of Bax Determine Its Function

Robin, Adeline Y., Iyer, Sweta, Birkinshaw, Richard W., Sandow, Jarrod, Wardak, Ahmad, Luo, Cindy S., Shi, Melissa, Webb, Andrew I., Czabotar, Peter E., Kluck, Ruth M., Colman, Peter M.

Journal:

Year:

2018

Language:

english

File:

PDF, 4.34 MB

english, 2018

28

Bcl-2 family-regulated apoptosis in health and disease

Journal:

Cell Health and Cytoskeleton

Year:

2010

Language:

english

File:

PDF, 1.68 MB

english, 2010

29

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation

Hockings, Colin, Iyer, Sweta, Uren, Rachel T., Kluck, Ruth M.

Journal:

Cell Death & Differentiation

Year:

2019

File:

PDF, 414 KB

2019

30

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation

Hockings, Colin, Iyer, Sweta, Uren, Rachel T., Kluck, Ruth M.

Journal:

Cell Death & Differentiation

Year:

2019

Language:

english

File:

PDF, 414 KB

english, 2019

31

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.

Journal:

Cell Death and Disease

Year:

2020

File:

PDF, 2.64 MB

2020